Amyotrophic Lateral Sclerosis, Chronic Stroke
Conditions
Brief summary
In the study we want to prove whether the subcutaneous application of granulocyte-stimulating factor (G-CSF) and erythropoetin (EPO) influence associative learning and/or motor skills of patients, who suffer from chronic stroke or amyotrophic lateral sclerosis. The study hypothesis is that G-CSF and EPO improve associative learning and/or motor skills.
Interventions
DRUGgranulocyte - colony stimulating factor (G-CSF)
DRUGerythropoetin (EPO)
Sponsors
University Hospital Muenster
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Diagnosis of chronic stroke or amyotrophic lateral sclerosis
Exclusion criteria
* leucocytes \> 10000/µl * hematocrit \> 48% * thrombocytes \< 150000/µl * severe rheumatoid arthritis * severe infection * severe liver or renal failure * severe arterial hypertension * recurrent thromboembolic events * severe coronary heart disease * myocardial infarction * malignant tumor * leukemia * peripheral arterial occlusion disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Learning success in a word learning model | — |
| Response time in motor function tests | — |
Secondary
| Measure | Time frame |
|---|---|
| Response time in a word learning model | — |
| Total time and number of keystrokes in motor function tests | — |
Countries
Germany
Outcome results
None listed