Oral Tolerance in Cow's Milk Allergy in the Infant

Oral Tolerance in Cow's Milk Allergy in the Infant: Role of CD4+CD25+ T Cells and Intestinal Microflora

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00298376

Enrollment

Registered

2006-03-02

Start date

2006-03-31

Completion date

Unknown

Last updated

2007-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cow's Milk Allergy

Keywords

Cow's milk allergy,, food allergy, oral tolerance,, infant,, regulatory T cells,, intestinal microflora

Brief summary

This study aims to determine if there is a link between cow's milk allergy in infants and regulatory T cells dysfunction that should be transient in infant acquiring oral tolerance after 12 month avoiding food and persistent in others. Cow's milk allergy is evaluated by basophils activation test, T cells activation test, specific humoral response (IgA, IgE, IgG) in allergic infants before and after 12 month avoiding food, before and after low dose milk exposure, before and after oral challenge. Number and function of regulatory T cells and microflora composition are measured at the same time. Allergic infants are compared to age matched control group.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

1 Months to 15 Months

Healthy volunteers

Yes

Inclusion criteria

male or female, age before 6 month, cow's milk allergy with positive prick or patch test for cow's milk Control group: male or female, age before 6 month or within 12 and 18 month, eating cow's milk every day

Exclusion criteria

immunodeficiency syndrome, lactose intolerance Control group: other food allergy, atopic dermatitis.

Countries

France

Contacts

Primary ContactFlorence VILLARD-TRUC, MD

fvillardtruc@hotmail.com33 472 110 390

Backup ContactDominique KAISERLIAN, PhD

kaiserlian@cervi-lyon.inserm.fr

Outcome results