Use of Probiotic Bacteria in Prevention of Allergic Disease in Children 1999-2008

Conditions

Allergic Conjunctivitis, Allergic Rhinitis, Seasonal, Asthma, Atopic Dermatitis, Food Hypersensitivity

Brief summary

The aim of the study is to find out if allergic diseases can be prevented buy giving probiotic bacteria to pregnant mothers and their newborn infants

Sampo Kallio, Ching Jian, Katri Korpela, Anna Kaarina Kukkonen, Anne Salonen et al. (8 authors)

Microbiology Spectrum2024-04-3018 citations

10.1128/spectrum.04135-23

Gut microbiota develop towards an adult profile in a sex-specific manner during puberty

Katri Korpela, Sampo Kallio, Anne Salonen, Matti Hero, Anna Kaarina Kukkonen et al. (14 authors)

Scientific Reports2021-12-0286 citations

10.1038/s41598-021-02375-z

Perinatal probiotic intervention prevented allergic disease in a Caesarean-delivered subgroup at 13-year follow-up.

Kallio S, Kukkonen AK, Savilahti E, Kuitunen M.

2018-12-1831 citations

10.1111/cea.13321

Probiotic supplementation restores normal microbiota composition and function in antibiotic-treated and in caesarean-born infants.

Korpela K, Salonen A, Vepsäläinen O, Suomalainen M, Kolmeder C, Varjosalo M, Miettinen S, Kukkonen K, Savilahti E, Kuitunen M, de Vos WM.

2018-10-16161 citations

10.1186/s40168-018-0567-4

FUT2-dependent breast milk oligosaccharides and allergy at 2 and 5 years of age in infants with high hereditary allergy risk.

Sprenger N, Odenwald H, Kukkonen AK, Kuitunen M, Savilahti E, Kunz C.

2016-02-2482 citations

10.1007/s00394-016-1180-6

Intestinal defensin secretion in infancy is associated with the emergence of sensitization and atopic dermatitis.

Savilahti EM, Kukkonen AK, Haahtela T, Tuure T, Kuitunen M, Savilahti E.

2011-11-1615 citations

10.1111/j.1365-2222.2011.03904.x

Interventions

DRUGMixture of probiotic bacteria and prebiotic oligosaccharide

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

37 Weeks to 42 Weeks

Inclusion criteria

* mother or father fo child with doctor diagnoses allergic disease

Exclusion criteria

* prematurity, major malformations

Countries

Finland

Outcome results

None listed