Diabetes Mellitus, Essential Hypertension, Renal Failure, Chronic Nephropathy
Conditions
Brief summary
Many patients with chronic renal disease show a loss of the nocturnal decline of blood pressure (non-dipper). However, the mechanism is not yet fully understood. We evaluate 24-hour blood pressure in patients with chronic renal disease using an ambulatory blood pressure monitoring device (A & D TM2425). We also analyze the power spectrum of heart rate variability as an index of autonomic cardiovascular modulation using the same device.
Detailed description
The ratio of lower frequency (LF) and higher frequency (HF) heart rate rhythmic oscillations is expressed as an index of sympathovagal balance. Patients with chronic renal disease participate in the study. Blood pressure and power spectrum of heart rate variability for 24 hours are measured when they receive no medication for at least 1 week. The mean waking and sleeping time systolic and diastolic blood pressure are calculated. LF/HF ratios in the chronic renal disease are evaluated to calculate the waking/sleeping ratio for LF/HF.
Interventions
Sponsors
Yokohama City University Medical Center
Study design
Observational model
NATURAL_HISTORY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Hypertensive patients with diabetes mellitus * Hypertensive patients * Hypertensive patients with renal disease * Patients with chronic renal disease
Exclusion criteria
* Cardiac, hematologic or hepatic disease * Cerebral infarction or hemorrhage * Other major diseases.
Countries
Japan
Outcome results
None listed