Cocaine Dependence
Conditions
Keywords
Cocaine; citalopram; impulsivity; serotonin
Brief summary
The purpose of this study is to compare the effects of citalopram versus placebo given in the context of contingency management for cocaine dependence.
Detailed description
Cocaine dependence continues to be a significant public health problem, for which there is no FDA approved pharmacotherapy. This study is a 12-week, double blind, placebo controlled trial of citalopram for cocaine dependence. The primary outcome measure is benzoylecgonine positive urines. Secondary measures of side effects and craving are also examined.
Interventions
DRUGcitalopram
Sponsors
National Institute on Drug Abuse (NIDA)
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* male and female subjects age 18 to 50 who currently meet DSM-IV criteria for cocaine dependence. * female subjects: a negative pregnancy test
Exclusion criteria
* current or past DSM-IV Axis I disorder other than substance abuse/dependence * any serious non-psychiatric medical illness requiring ongoing medical treatment * substance dependence other than cocaine within the last 3 months * negative urine drug screen for cocaine at time of testing * for female subjects: a positive pregnancy test
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The presence of cocaine metabolites in urine weekly. | — |
Secondary
| Measure | Time frame |
|---|---|
| Retention rate and cocaine cravings weekly. | — |
Countries
United States
Outcome results
None listed