Comparison of the Effects of Phenylephrine and Norepinephrine on Cardiac Function During Carotid Artery Surgery

Comparison of the Effects of Phenylephrine and Norepinephrine on Cardiac Function During Carotid Cross-Clamping During Carotid Endarterectomy Under General Anesthesia

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00294606

Enrollment

Registered

2006-02-22

Start date

2006-02-28

Completion date

2006-02-28

Last updated

2006-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Echocardiography, Transesophageal, Endarterectomy, Carotid, Vasopressor Agents

Keywords

vasopressor agents, carotid endarterectomy, cardiac function, transesophageal echocardiography, wall motion abnormalities

Brief summary

This will be a prospective, randomized, double-blinded, cross-over clinical trial to compare the effects of phenylephrine or norepinephrine on cardiac function during carotid artery surgery in patients under general anesthesia. The effect of the vasopressor on cardiac function will be measured using electrocardiography, transesophageal echocardiography and cardiac troponin I intraoperatively and postoperatively. We will use a cross-over pattern since both drugs exhibit rapid onset and short duration of action. We hypothesize that there will be less myocardial ischemia associated with the use of norepinephrine when compared with phenylephrine during carotid artery surgery.

Interventions

DRUGComparison of Effects of Phenylephrine and Norepinephrine

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Elective carotid endarterectomy under general anesthesia * \> 18 years old * Written informed consent

Exclusion criteria

* Contraindication to general anesthesia * Contraindication to transesophageal anesthesia * esophageal disease * esophageal stricture * history of esophageal or gastric bleeding * esophageal anatomic abnormality * past esophageal or gastric surgery * severe dysphagia

Design outcomes

Primary

Measure	Time frame
Myocardial ischemia measures by transesophageal echocardiography and ST segment analyses	—

Secondary

Measure	Time frame
Myocardial ischemia measures by cardiac troponin I	—

Countries

Canada

Contacts

Primary ContactRosemary A Craen, MD, FRCPC

rosemary.craen@lhsc.on.ca(519) 663-3022

Backup ContactHélène G Pellerin, MD, FRCPC

hpelleri@uwo.ca(519) 663-3022

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026