Colorectal Surgery
Conditions
Keywords
Antibiotics, Prophylaxis, Surgical wound infection
Brief summary
To determine the optimal prophylactic antibiotics administration method in elective colorectal surgery
Detailed description
Use of prophylactic antibiotics in elective colorectal surgery is essential. Although single-dose prophylactic antibiotics are recommended, the efficacy of single-dose cephalosporin without metronidazole and oral antibiotics is not fully proven. We conducted a multicenter randomized trial of single-dose vs. three doses of the second-generation cephalosporin, cefmetazole.
Interventions
Sponsors
National Cancer Center, Japan
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Colorectal diseases (cancer, large polyp, carcinoid, lymphoma,sarcoma and so on) * Elective colorectal resection
Exclusion criteria
* Emergent operation * Ileus * No resection * Preoperative infectious diseases * Penicillin or cephalosporin allergy * Antibiotics administration before surgery * Inflammatory bowel diseases * Angina or myocardial infarction * Renal dysfunction * Diabetes mellitus * Steroid administration before surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of incisional surgical site infection (SSI) | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidences of organ/space SSI and other infectious diseases. Other postoperative complications and postoperative hospital stay | — |
Countries
Japan
Outcome results
None listed