Simvastatin Effect on End Stage Renal Failure Patients Treated by Peritoneal Dialysis

Simvastatin Effect on Endothelium Dependent Venodilation in Chronic Renal Failure Patients Treated by Peritoneal Dialysis

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00291863

Enrollment

Registered

2006-02-15

Start date

2006-02-28

Completion date

2006-02-28

Last updated

2006-02-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peritoneal Dialysis, Renal Failure, End Stage

Keywords

end stage renal failure, peritoneal dialysis, simvastatin, endothelium, vasodilation

Brief summary

This study will analyse the effect of simvastatin on endothelium dependent venodilation in chronic renal failure patients treated by peritoneal dialysis. The hypothesis is that patients will have a greater endothelium dependent venodilation after four months of simvastatin use.

Detailed description

Interventions

DRUGSimvastatin

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* end stage renal failure * peritoneal dialysis * LDL cholesterol \> 100mg/dL * \> 18 years and \< 80 years

Exclusion criteria

* using statin or nitrate * liver disease * diabetes mellitus

Design outcomes

Primary

Measure	Time frame
endothelial venodilation	—

Secondary

Measure	Time frame
Inflammation markers (C-reactive protein, IL-6, TNF)	—
Lipoproteins	—
Oxidative stress	—

Countries

Brazil

Contacts

Primary ContactMaristela Bohlke, MD

mbohlke@conesul.com.br55 53 32264098

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026