PGI2 Induced Headache and Cerebral Haemodynamics in Healthy Volunteers

Status

Terminated

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00291395

Enrollment

Registered

2006-02-14

Start date

2005-09-30

Completion date

Unknown

Last updated

2006-10-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Headache, Migraine

Brief summary

Before , during and after intravenous administration of PGI2 we score/measure headache, rCBF, blood flow in middle cerebral artery and diameter of superficial temporal artery/radial artery and correlate that to known patophysiology of headache to see if PGI2 is involved in headache pathophysiology.

Interventions

DRUGPGI2

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy volunteers,

Exclusion criteria

* Primary headache, * headache on the day of investigation, * Hypertension, * hypotension, * pregnant/nursing * Daily intake of medication (except oral contraceptives) * Cardiovascular or CNS disease * Drug/Alcohol abuse * Psychiatric disease

Design outcomes

Primary

Measure	Time frame
Headache	—

Secondary

Measure	Time frame
rCBF, blood flow, diameter of STA/RA, HR, BP	—

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026