Effect of Partial Sleep Deprivation on Cognition and Cytokines in Individuals With Major Depression

Phase 4 Study on the Effect of Partial Sleep Deprivation on Cognition and the IL-6-gp130-System in Individuals With Major Depression

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00291239

Enrollment

Registered

2006-02-13

Start date

2006-02-28

Completion date

2009-07-31

Last updated

2009-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major Depression

Brief summary

40 patients with the diagnosis of major depression are included. There are two interventions: partial sleep deprivation (PSD) and normal night sleep (CTRL). Patients are randomly assigned to PSD-(2 undisturbed nights)-CTRL or CTRL-(2 undisturbed nights)-PSD. Cytokine-status, neuropsychological and psychopathometric status are assessed pre and post each interventional and control condition.

Interventions

BEHAVIORALpartial sleep deprivation

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Major depression * Informed consent

Exclusion criteria

* Known epilepsy or previous unexplained loss of consciousness after sleep deprivation * Bipolar disorder * Acute or chronic inflammatory diseases * Psychosis * Suicidal tendency * Pregnancy or nursing

Design outcomes

Primary

Measure	Time frame
cognition	—
cytokine concentration	—

Secondary

Measure	Time frame
clinical improvement	—

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026