Diabetes Mellitus, Type 2
Conditions
Keywords
Blood Pressure,, rosiglitazone,Diabetes Mellitus, Type 2,
Brief summary
The purpose of this study was to determine the effects of rosiglitazone in normotensive type 2 diabetic patients with regard to its blood-pressure-reducing effects.
Detailed description
The first study to evaluate the effects of troglitazone on blood pressure in humans was published recently, which demonstrated a 5/4 mm Hg reduction in ambulatory blood pressure in 18 nondiabetic obese subjects after 12 weeks' treatment. Another study in 18 hypertensive subjects with diabetes mellitus showed an 18/12 mm Hg decline in office blood pressure after 8 weeks of treatment.
Interventions
DRUGrosiglitazone(drug), blood pressure lowering effect
Sponsors
Baskent University
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
49 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Blood pressure of patients were in normotensive limits according to the JNC VII * Diabetes mellitus treated with oral antidiabetics or diet
Exclusion criteria
* Any known hypertension, coronary artery disease, congestive hearth failure, renal disease or liver disease * Anti-hypertensive treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ambulatory blood pressure monitors used to determine the subjects blood pressure before and after the treatment. At the end of three months period wit rosiglitazone treatment diastolic blood pressure decreased. | — |
Countries
Turkey (Türkiye)
Outcome results
None listed