Hayfever
Conditions
Keywords
Nasal allergen challenge, Allergic rhinitis, Timothy grass pollen, inflammatory mediators
Brief summary
This is a non-drug, biomarker study to assess the utility of the model of repeated nasal allergen challenges in subjects with atopic rhinitis as a method of inducing an increased response to inhaled allergen, which will more closely resemble the responses seen during the hayfever season.
Detailed description
This is a non-drug, biomarker study to assess the utility of the model of repeated nasal allergen challenges in subjects with atopic rhinitis as a method of inducing an increased response to inhaled allergen, which will more closely resemble the responses seen during the hayfever season.
Interventions
PROCEDURESkin Prick Test
PROCEDURENasal allergen challenge
PROCEDURENasal filter paper placement
PROCEDURENasal lavage
PROCEDURENasal scrape
PROCEDURENasal symptoms score
Sponsors
Novartis Pharmaceuticals
Imperial College London
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
1. Male and female subjects with a history of seasonal (intermittent) atopic rhinitis, aged 18-40 years. 2. Otherwise healthy with no health problems that may jeopardize the subjects participating in the study, absence of history of other significant allergies.
Exclusion criteria
1. Smokers (use of tobacco products in the previous 3 months). 2. Presence of any respiratory disease other than a history of mild stable asthma not requiring treatment and associated with normal lung function (FEV1 \> 80% predicted at screening).
Countries
United Kingdom
Outcome results
None listed