Surgical Intervention for Morbidly Obese Adolescents

Conditions

Diabetes, Hypertension, Obesity

Keywords

Obesity, Surgery, Adolescent, Roux-en-Y gastric bypass, Laparoscopic

Brief summary

The purpose is to study whether the positive effects from obesity surgery in adults also can be achieved when adolescent subjects are operated. Our hypothesis is that the effects concerning weight loss, health improvement and improved quality of life will be as good in adolescents as in adults.

Detailed description

Severe obesity in the adolescence is a major concern since there is a constant rise in prevalence worldwide. There is a need of effective tools to treat those patients since the natural course with conservative treatment is very pessimistic. I. e. most of the subjects having a BMI \>40kg/m2 in the adolescence will remain morbidly obese also in their adult life. The three largest centres in Sweden treating obese children (Stockholm, Gothenburg and Malmö) will offer patients fulfilling the inclusion criteria to be operated with laparoscopic gastric bypass. If not willing to be operated they could join the study as a control case. Subjects will be investigated at the baseline concerning physical health status and existence of medical risk factors but also regarding their quality of life, eating habits and physical activity. They will subsequently be follow over a ten year period regarding these variables.

Kajsa Järvholm, Torsten Olbers, Markku Peltonen, Claude Marcus, Carl‐Erik Flodmark et al. (8 authors)

Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity2020-10-2014 citations

10.1007/s40519-020-01024-0

5-year mental health and eating pattern outcomes following bariatric surgery in adolescents: a prospective cohort study.

Järvholm K, Bruze G, Peltonen M, Marcus C, Flodmark CE, Henfridsson P, Beamish AJ, Gronowitz E, Dahlgren J, Karlsson J, Olbers T.

2020-01-2144 citations

10.1016/s2352-4642(20)30024-9

Laparoscopic Roux-en-Y gastric bypass in adolescents with severe obesity (AMOS): a prospective, 5-year, Swedish nationwide study.

Olbers T, Beamish AJ, Gronowitz E, Flodmark CE, Dahlgren J, Bruze G, Ekbom K, Friberg P, Göthberg G, Järvholm K, Karlsson J, Mårild S, Neovius M, Peltonen M, Marcus C.

2017-01-06198 citations

10.1016/s2213-8587(16)30424-7

Interventions

PROCEDURESurgery

Laparoscopic Roux-en-Y gastric bypass

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

13 Years to 17 Years

Healthy volunteers

No

Inclusion criteria

* BMI \>40 kg/m2 or BMI\>35 with comorbidity * Pass psychological evaluation * Puberty status Tanner 4-5 * At least one year with active conservative treatment that failed

Exclusion criteria

* Lack of compliance * Specific obesity syndrome as Praeder Willis * Obesity due to brain injury * Severe general disease * Specific genetic defect (MC4R, Leptin deficiency)

Design outcomes

Primary

Measure	Time frame
BMI development	10 years

Secondary

Measure	Time frame
Medical risk factors, incidence of diseases (such as diabetes, hypertension etc), quality of life, socioeconomic development, eating pattern.	10 years

Countries

Sweden

Outcome results

None listed