Hyperpigmentation, Nevus
Conditions
Keywords
Acquired bilateral nevus of Ota-like macules, Postinflammatory hyperpigmentation, Cold air cooling
Brief summary
\- To investigate the benefit of epidermal cooling on the incidence of post inflammatory hyperpigmentation after laser irradiation
Detailed description
* 70% incidence of post inflammatory hyperpigmentation has been reported following a Q-switched nd:YAG laser treatment of acquired bilateral nevus of Ota-like macules. * We assumed that epidermal cooling may minimize the non-specific injury to the epidermis caused during laser irradiation, leading to the decreased incidence of post inflammatory hyperpigmentation.
Interventions
DEVICECold air cooling
Sponsors
Mahidol University
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Subjects with acquired bilateral nevus of Ota-like macules. * At least 18 years old * No previous treatment on the condition for a minimum period of 1 month.
Exclusion criteria
* Subjects diagnosed of scleroderma, connective tissue disorders, hematologic disorders, hepatitis, infection, or uncontrolled DM * History of keloid and/or hypertrophic scar. * Currently on anti-coagulant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of post inflammatory hyperpigmentation | 2 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Side effects of cold air cooling and clearing rate of pigmented lesion | 12 weeks |
Countries
Thailand
Outcome results
None listed