Dyspepsia
Conditions
Keywords
H. Pylori, Clarithromycin resistant, gene
Brief summary
Peptic ulcer disease is the most common gastrointestinal disease. Antibiotic resistant Helicobacter pylori is a major problem worldwide. The gold standard for Helicobacter pylori eradication is composed of Proton-pump inhibitor/Ranitidine bismuth citrate + Amoxycillin + Metronidazole /Clarithromycin. In Thailand, clarithromycin resistant strains increased and led to treatment failure. Data on file at Rajavithi Hospital showed that metronidazole resistant H. pylori was about 50% and Clarithromycin resistant strains accounted for 8%. This molecular genetic study will be performed in patients presenting with dyspepsia, who had an indication for gastroscopic examination, to explore the incidence of antibiotic resistant Helicobacter pylori in Rajavithi Hospital, Thailand.
Detailed description
Genetic and Biomolecular factors determining clarithromycin resistance will be characterized.
Interventions
PROCEDUREgastroscopic examination
gastroscopic examination for tissue biopsy and real time PCR for gene study
Sponsors
Department of Medical Services Ministry of Public Health of Thailand
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
15 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* male or female with dyspepsia * age \> 15 years * fulfil indication for gastroscopic examination * able to give informed consent
Exclusion criteria
* contraindication for gastroscopic examination and biopsy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of H. pylori Clarithromycin resistance gene | one year |
Secondary
| Measure | Time frame |
|---|---|
| Characteristic of H. pylori clarithromycin resistant gene mutation | one year |
Countries
Thailand
Outcome results
None listed