The Effect of Obesity on Lung Functioning

The Effect of Medical and Surgical Weight Loss on Pulmonary Physiology and Airway

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00284895

Enrollment

Registered

2006-02-01

Start date

2005-11-30

Completion date

2007-11-30

Last updated

2017-03-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma, Obesity

Keywords

Obesity, Bariatric Surgery, Weight Loss Surgery, Asthma

Brief summary

This research study is looking at the effects of weight loss, due to surgery or structured weight-loss program on lung function, inflammation in your body and lungs, asthma and asthma symptoms. This study is important because we will be better able to understand the effect of weight on lung functioning and asthma. Approximately 20 research subjects will be enrolling in this study at National Jewish. Adults with asthma who has elected to undergo weight-reduction surgery may qualify for the participation. Involvement will last about 1 year.

Interventions

None listed

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Adults (≥18yr) who report a physician's diagnosis of asthma and have taken any asthma medication within the last 2 weeks. * Obesity (Body Mass Index (BMI) ≥40, or ≥35 with comorbidities, as per published guidelines for qualification for bariatric surgery). * Planned weight-loss surgery or structured weight-loss plan.

Exclusion criteria

* Tobacco use within one month. * Qualifying lung-functioning. * Qualifying oxygen saturation levels. * Use of systemic corticosteroids (Prednisone) within one month. * Presence of another chronic lung disease besides asthma (COPD, bronchiectasis, ILD, sarcoidosis, etc). * Presence of another chronic systemic inflammatory disease (rheumatoid arthritis or other connective-tissue disease, chronic infection such as osteomyelitis, inflammatory bowel disease, chronic active hepatitis, etc). Subjects with osteoarthritis, stable coronary artery disease, hypertension, or diabetes mellitus will not be excluded. * Presence of malignant neoplasm within the last 3 years (with the exception of non-melanoma skin cancer). * Clinically significant left or right ventricular dysfunction. * Severe pulmonary hypertension (high blood pressure). * Untreated obstructive sleep apnea: * Subjects with a current diagnosis of sleep apnea not being treated with CPAP or BiPAP will be excluded. * Subjects with a current diagnosis of sleep apnea being treated adequately (as determined by the investigators) will be included. * Prader-Willi syndrome * A known endocrinopathy causing obesity (e.g., Cushing's Syndrome).

Countries

United States

Outcome results