The Effect of Cold Storage Solutions on Ischemic Injury in Lung Transplantation

A Prospective, Controlled, Randomized Study on the Effect of Cold Storage Solutions on Complement Activation and Other Mediators of Ischemic Injury in Lung Transplantation

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00284726

Enrollment

Unknown

Registered

2006-02-01

Start date

2000-12-31

Completion date

2005-09-30

Last updated

2023-09-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Transplant Recipients

Keywords

Cytokines in lung transplantation, Cold storage solutions, Ischemic reperfusion injury

Brief summary

The purpose of this study is to compare 2 different cold storage solutions, used to preserve donor lungs for lung transplantation, and their effect on cytokine activation related to ischemic reperfusion injury. Primary endpoint is 30 day survival.

Detailed description

The length of ischemic time in harvesting lung allografts is associated with graft survival. It is further thought that ischemic changes in early post-transplantation bronchoscopic biopsies has a direct correlation with later development of chronic rejection.

Interventions

DEVICECelsior Cold Storage Solution

Eligibility

Sex/Gender

ALL

Inclusion criteria

Any patient undergoing a lung trasnplant at Johns Hopkins Hospital -

Exclusion criteria

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026