Non-invasive Diagnosis of Coronary Artery Stenoses by Doppler Echocardiography

Non-invasive Evaluation of Coronary Pathology by Transthoracic Doppler Echocardiography. A Comparative Study to Coronary Angiography.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00281346

Enrollment

110

Registered

2006-01-24

Start date

2005-12-31

Completion date

2008-08-31

Last updated

2016-07-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stable Angina Pectoris, Unstable Angina Pectoris, Acute Myocardial Infarction

Keywords

Doppler echocardiography, coronary stenosis, Coronary angiography

Brief summary

Non-invasive evaluation of patients with stable angina and unstable coronary syndromes with transthoracic Doppler echocardiography to evaluate presence of significant coronary stenoses. Blinded evaluation and comparison with coronary angiography: presence and location of stenoses, and head to head comparison of clinical value and patient classification.

Detailed description

Transthoracic Doppler echocardiographic evaluation with extensive evaluation of coronary stenoses in all 3 main branches using colour flow, pulsed Doppler and Coronary flow velocity reserve (CFVR)after pharmacologic stress with adenosin in the area of LAD and RDP. Blinded evaluation of Doppler results and coronary angiography regarding the other examination modality. Coronary angiography diagnostic gold standard. Only stable and unstable patients otherwise scheduled for angiography on clinical reasons will be examined and included in the study. Added January 2007 after ethics committee approval: comparison of CFVR with invasive fractional flow reserve (FFR) in selected subset of patients.

Interventions

PROCEDUREDoppler echocardiography

Echocardiography

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

* unstable angina or acute myocardial infarction, or stable angina pectoris and * scheduled for coronary angiography on accepted clinical reasons

Exclusion criteria

* past coronary artery grafting

Design outcomes

Primary

Measure	Time frame
Diagnostic yield: Accuracy, positive and negative predictive value.	Inhospital
pr patient evaluation	Inhospital

Secondary

Measure	Time frame
pr stenosis evaluation	Inhospital

Countries

Norway

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026