Hemophilia A
Conditions
Keywords
haemophilia A, thrombelastography, recombinant factor VIII, thrombin generation
Brief summary
In the present study we are examining the clot formation and clot stability in patients with severe haemophilia A after they receive recombinat factor VIII and after addition of tranexamic acid. Our hypothesis is that addition of tranexamic increases the clot stability. The perpective of the study is to document whether it is relevant to use traneksamic acid in surgery in patients with severe haemophilia A.
Detailed description
In the present study we are examining the clot formation and clot stability in patients with severe haemophilia A after they receive recombinat factor VIII and after addition of tranexamic acid. Our hypothesis is that addition of tranexamic increases the clot stability. The perpective of the study is to document whether it is relevant to use traneksamic acid in surgery in patients with severe haemophilia A.
Interventions
DRUGReFacto (Recombinant factor VIII) and Tranexamic acid
Sponsors
University of Aarhus
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Severe haemophilia A * Above 17 years old * Thrombocyt count above 100 x 109/l within the past two years
Exclusion criteria
* Received recombinant factor VIII with in the past 3 days * Inhibitor against recombinant factor VIII * HIV-positive * Ongoing treatment for hepatitis C * Known kidney disease * Allergy against Tranexamic acid * Not able to give informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clot stability | — |
Secondary
| Measure | Time frame |
|---|---|
| clot formation,thrombine generation | — |
Countries
Denmark
Outcome results
None listed