Coronary Artery Disease, Obesity
Conditions
Keywords
coronary artery disease, epicardial adipose tissue, epicardial fat, obesity
Brief summary
We sight to evaluate whether patients with coronary artery disease (CAD) have more epicardial fat than patients without CAD, which would suggest that epicardial fat may be more than an innocent bystander and be actively involved in the disease process. Its role as a modulator of vascular response and myocardial function could potentially lead to new areas of cardiac research. We also sight to evaluate whether epicardial fat from patients with CAD releases more adipokines than subcutaneous fat from these patients which could prompt studies into the differential regulation of adipokine secretion in this tissue. Thus for e.g., the use of thiazolidinediones (glitazones), statins, ARBs or other compounds that can specifically modulate adipokine secretion could be explored to determine their benefit in ameliorating the effects attributable to increased epicardial fat.
Interventions
None listed
Sponsors
Heart and Stroke Foundation of Canada
Hamilton Health Sciences Corporation
Study design
Observational model
DEFINED_POPULATION
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients elegible for elective cardiac surgery are elegible * Ability to provide written informed consent in accordance with GCP guidelines and local legislations. * \> 18 years of age
Exclusion criteria
* Control patients will not have clinical signs of CAD and will show normal coronary arteries on angiography. * Any medical, social or geographic condition, which, in the opinion of the investigator would not allow safe or reliable completion of the protocol.
Countries
Canada
Contacts
Primary ContactSuzana Damjanovic, MLT, CCRA
Outcome results
None listed