Peptic Ulcer Hemorrhage
Conditions
Brief summary
Endoscopic treatment of bleeding peptic ulcers is effective to prevent rebleeding. Adjuvant medical treatment to increase gastric pH may further decrease rebleeding. Recent studies on potent acid suppression by proton pump inhibitors (PPI) demonstrated the efficacy in preventing rebleeding. Lau demonstrated that high dose intravenous infusion of omeprazole decreased rebleeding in peptic ulcers with stigmata of recent hemorrhage. There is little data regarding the effect of pantoprazole on bleeding peptic ulcers. Furthermore, the optimal dose of PPI is unknown. Few studies have included measurement of gastric pH in addition to clinical outcome. This study compares the effect of two doses of intravenous pantoprazole with no acid suppression in bleeding peptic ulcers after endoscopic therapy. In addition to the usual clinical endpoints, gastric pH is monitored to study the relation of pH elevation and the clinical outcome.
Interventions
DRUGpantoprazole infusion
DRUGpantoprazole bolus
DRUGno treatment
Sponsors
Kwong Wah Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
0 Years to No maximum
Inclusion criteria
* patients presenting with upper gastrointestinal bleeding with upper endoscopy showing a bleeding peptic ulcer with major stigmata of haemorrhage and after successful endoscopic haemostasis.
Exclusion criteria
* previous gastrectomy and vagotomy * patient taking warfarin * intake of anti-secretory drugs in the previous 48 hours
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rebleeding rate within 30 days after endoscopic therapy | — |
Secondary
| Measure | Time frame |
|---|---|
| duration of hospital stay | — |
| need for operative intervention | — |
| Transfusion requirement | — |
| gastric pH | — |
| side effects of pantoprazole | — |
| mortality rate | — |
Countries
China
Outcome results
None listed