Anaemia, Helminthiases, Schistosomiasis
Conditions
Keywords
iron deficiency schistosomiasis soil transmitted helminths
Brief summary
The objectives of this study is: * to establish the coverage rate of weekly iron supplementation in children in intervention schools over a period of nine months * document any side effects of weeekly iron supplementation among children in intervention schools over a period of nine months asses the feasibility of incorporating the weekly iron supplementation programme into the normal school activity in intervention schools determine the extent of acceptability and support for the iron supplementation programme by staff at the health centre nearest to the intervention schools * compare the praziquantel efficacy and schistosomiasis reinfection in children in intervention schools with that of children in control schools following the introduction of weekely iron supplementation over a period of nine months * determine the impact of weekly iron supplementation on haemoglobin levels of children in intervention schools and compare with children in control schools over a period of nine months
Detailed description
Iron deficiency anaemia is a common denominator for both schistosomiasis and soil transmitted helminths. Iron deficiency appears to affect the immune response against schistosomes and intestinal helminths. It therefore follows that correcting the iron deficiency anaemia will improve the efficacy of anthelminthics such as praziquantel (against schistosomiasis) and albendazol (against soil transmitted helminths) and ability of the host immune system to resist reinfection with schistosomes and soil transmitted helminths. The aim of this study is to identify factors necessary for a successful weekly iron supplementation programme in schistosomiasis and soil transmitted helminths control programmes. In addition impact of weekly iron supplementation programme n haemoglobin levels, efficacy of praziquantel, and schistosomiasis re-infection will be studied.
Interventions
DRUGferrous sulphate (drug)
Sponsors
DBL -Institute for Health Research and Development
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
9 Years to 15 Years
Healthy volunteers
Yes
Inclusion criteria
all schoolchildren, in grade 2 and 3, at four selected schools -
Exclusion criteria
\-
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood samples examined for haemoglobin level mont 0 and month 9 | — |
| Urine samples examined for schistsoma haematobium at month 0, 3. 6 and 9 | — |
| Stool samples examined for schistsoma mansoni at mont 0, 3, 6 and 9 | — |
Secondary
| Measure | Time frame |
|---|---|
| nausea | — |
| vomiting | — |
| body weakness | — |
| diarrhoea | — |
| abdominal pain | — |
| others | — |
| Any side effects to iron supplementation, measured every week for the first foru weeks after treatment start. Mesured on: | — |
| - headache | — |
Countries
Zambia
Outcome results
None listed