Open-Angle Glaucoma
Conditions
Brief summary
To compare the intraocular pressure effect and safety of the dorzolamide/timolol fixed combination given twice daily versus bimatoprost given once every evening in patients with open-angle glaucoma in patients insufficiently controlled on latanoprost monotherapy
Interventions
Sponsors
Pharmaceutical Research Network
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* adults with a diagnosis of bilateral open-angle glaucoma including: primary, pigment dispersion or exfoliation in both eyes * on no therapy the intraocular pressure should be 22-29 mm Hg inclusive at the 8:00 AM measurement * visual acuity should be 20/200 or better in each eye
Exclusion criteria
* historical failure to respond to topical beta-blockers in a clinically meaningful manner * any contraindication to study medications * any anticipated change, or modification in the 6 weeks prior to Visit 1, in systemic hypertensive therapy during the trial
Countries
United States
Outcome results
None listed