Headache, Migraine, Ultrasonography, Doppler, Transcranial, Vasoactive Intestinal Peptide
Conditions
Keywords
Migraine, VIP, Transcranial Doppler, Headache
Brief summary
We hypothesized that infusion of VIP may induce headache/migraine in migraineurs and that VIP-induced headache may be associated with dilation of intra- and extracranial vessels. To test this hypothesis, we performed a double blind placebo-controlled crossover study in migraineurs and studied the effect on headache and cerebral and systemic hemodynamic parameters.
Detailed description
We hypothesized that infusion of VIP may induce headache/migraine in migraineurs and that VIP-induced headache may be associated with dilation of intra- and extracranial vessels. To test this hypothesis, we performed a double blind placebo-controlled crossover study in migraineurs and studied the effect on headache and cerebral and systemic hemodynamic parameters. The subjects were randomly allocated to the infusion of 8pmol/kg/min VIP or placebo (isotonic saline), duration 25min. Headache intensity, mean velocity of blood flow in the middle cerebral artery (VmMCA), superficial temporal artery diameter, end-expiratory CO2 and vital signs were recorded at baseline and then every 10 min until 120 min after start of the infusion. The patients received a headache diary for the following 12 hours after infusion.
Interventions
Sponsors
Danish Headache Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
DIAGNOSTIC
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* migraineurs
Exclusion criteria
* cerebrovascular disorders, pregnancy, nursing
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Headache | — |
| Intra- and extracranial vasodilation | — |
Secondary
| Measure | Time frame |
|---|---|
| arterial blood pressure | — |
| heart rate | — |
Countries
Denmark
Outcome results
None listed