Effects of Sleep Loss on Endothelial Function and Cytokine Levels in Internal Medicine Residents

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00272233

Enrollment

Registered

2006-01-04

Start date

2004-12-31

Completion date

2005-06-30

Last updated

2007-03-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sleep Deprivation

Keywords

Inflammation Mediators [D23.469], Cardiovascular Physiologic Phenomena [G09.330.553]

Brief summary

Work requirements for medical trainees result in substantial sleep loss. Sleep loss has been associated with increased levels of certain inflammatory hormones that could have negative impact on blood vessel function. The purpose of this study is to determine the effects of sleep loss on blood hormone levels and blood vessel function in medical trainees.

Detailed description

Context: Sleep loss is associated with increased blood levels of interleukin-6 (IL-6) and C-reactive protein (CRP). Medical residents are often deprived of normal sleep during extended work shifts, but the effects of work-related sleep loss on biomarkers of vascular inflammation and function are unknown. Objective: We sought to test the hypothesis that sleep loss during extended work shifts during medical training is associated with increased circulating levels of pro-inflammatory biomarkers and evidence of vascular dysfunction. Design: Outcome measures were assessed after extended 30-hour work shifts and non-extended 6-hour work shifts in a single-blind, randomized crossover design. Setting: University hospital medical intensive care unit Patients or Other Participants: Twenty-two healthy medical residents were studied during a medical intensive care unit rotation. Main Outcome Measure(s): Sleep related cytokines (interleukin-6 and tumor necrosis factor), serum markers of vascular inflammation (C-reactive protein), and flow-mediated dilation in the brachial artery.

Interventions

None listed

Study design

Observational model

DEFINED_POPULATION

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Medical resident in MICU rotation * Non-smoker * Body mass index \<28 kg/m2

Exclusion criteria

* Systolic blood pressure \>140 mmHg; Diastolic blood pressure \>90 mmHg * Known history of diabetes mellitus, hypertension, hyperlipidemia * Known history of acute or chronic inflammatory or infectious disease * Known history of sleep disturbance unrelated to work * Pregnancy

Countries

United States

Outcome results