Bipolar Depression
Conditions
Keywords
Bipolar Depression, Escitalopram, Mood Stabilizer, Atypical Antipsychotic
Brief summary
To determine if adding Escitalopram to current mood stabilizer (MS) or atypical antipsychotic (AA) will improve in rates similar to or better than adding a placebo (inactive pill)in resistant bipolar patients.
Interventions
DRUGEscitalopram
10mg to 20mg tablet daily for 6 weeks
DRUGplacebo
Sponsors
Queen's University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 18 or older * Diagnosis of Bipolar Disorder and currently be in depressive state, and not responded to mood stabilizer or atypical antipsychotic alone or combined with an antidepressant medication.
Exclusion criteria
* Pregnant or breastfeeding * History of seizure disorder or other unstable medical condition * Received Electroconvulsive Therapy or Transcranial Magnetic Stimulation in the last three months * Experienced hallucinations or delusions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the response rates when Escitalopram vs. placeboes added to the current mood stabilizer or antipsychotic medication | 6 weeks |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate efficacy, safety and tolerability of added Escitalopram, to a mood stabilizer or atypical antipsychotic. | 6 weeks |
Countries
Canada
Outcome results
None listed