The Effects of Marijuana on Orientation and Motor Coordination and Brain Metabolism in Regular Smokers of Marijuana

The Effects of Marijuana on Orientation and Motor Coordination and Brain Metabolism in Regular Smokers of Marijuana.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00270803

Enrollment

Registered

2005-12-28

Start date

2004-07-31

Completion date

2005-12-31

Last updated

2008-05-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Marijuana Dependence

Keywords

Marijuana, FDG, PET, maze, THC, motor coordination.

Brief summary

This study investigates the effects of 17mg and 13mg Delta THC on orientation and motor coordination and brain metabolic activity in regular users of marijuana. Subjects were tested twice, after smoking cigarettes with marijuana and after smoking cigarettes without marijuana.On both occasions they performed on a virtual reality maze task. They were afterwards scanned in Positron Emission Tomography (PET) with Fluoro-deoxy-glucose (FDG).

Detailed description

This study investigates the effects of 17mg and 13mg Delta THC on orientation and motor coordination and brain metabolic activity in regular users of marijuana. Subjects were tested twice, after smoking cigarettes with marijuana and after smoking cigarettes without marijuana. On both occasions they performed on a virtual reality maze task. They were afterwards scanned in Positron Emission Tomography (PET) with Fluoro-deoxy-glucose (FDG). 12 subjects were tested so far on both conditions.

Interventions

DRUGTetra Hydro Cannabinol (THC)

Oral THC 13mg and 17mg smoked in low nicotine cigarettes

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* Marijuana dependence * Age 20-65 * Male and female

Exclusion criteria

* Pregnant women * Dependence on other substances * Psychiatric diagnosis apart from marijuana dependence * Neurological disorder * Young persons

Design outcomes

Primary

Measure	Time frame
Brain metabolic activity (FDG)	30-40 minutes

Secondary

Measure	Time frame
Reaction time (RTs) and errors in performance	40 minutes
Subjective ratings on visual analog scale	10 minutes

Countries

Israel

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026