Physical Activity, Insulin Resistance and Function of Fat Tissue in the Offspring of Patients With Type 2 Diabetes

Physical Activity, Insulin Resistance and Adipose Tissue Gene Expression in the Offspring of Patients With Type 2 Diabetes

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00268541

Enrollment

Registered

2005-12-22

Start date

2004-09-30

Completion date

2007-02-28

Last updated

2007-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular Diseases, Type 2 Diabetes Mellitus

Keywords

exercise, physical activity, insulin resistance, adipose tissue, gene expression

Brief summary

Offspring of patients with type 2 diabetes have increased risk of developing diabetes and are typically more insulin resistant than their peers with no diabetes family history. We have recently demonstrated that, in contrast to their sedentary counterparts, physically active offspring are not insulin resistant. In the proposed controlled clinical study, we will examine the effects of a moderate exercise programme on insulin resistance, and other metabolic risk factors, in sedentary offspring and matched control subjects. We hypothesise that offspring will exhibit an augmented response to exercise, thereby normalising their predisposition to an adverse metabolic profile. We will also investigate expression of adipokines and other genes in adipose tissue to determine whether these contribute to the increased insulin resistance observed in offspring and whether they are influenced by exercise. The results will help to determine the efficacy of exercise in normalising metabolism in offspring and will help elucidate the mechanisms involved.

Interventions

BEHAVIORALPhysical activity

Study design

Allocation

RANDOMIZED

Intervention model

FACTORIAL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* 2 subject groups - 'control' and 'offspring' * Offspring - at least 1 parent diagnosed with type 2 diabetes before age 65 * Controls - no history of type 2 diabetes in 1st or 2nd degree relatives * In generally good health * Non-smoker * Fasting glucose \< 7 mmol/l * Blood pressure \<160/90 mm Hg * No established CHD (e.g. MI, stroke, CABG, PCTA)

Exclusion criteria

* Established CHD (e.g. MI, stroke, CABG, PCTA) * diabetes * smoking * hypertension (BP \> 160/90 mmHg) * pregnancy

Design outcomes

Primary

Measure	Time frame
Insulin resistance at 8 weeks	—
Risk markers for cardiovascular disease/diabetes at 8 weeks	—
Adipose tissue gene expression at 8 weeks	—

Secondary

Measure	Time frame
Fitness at 8 weeks	—
Body composition/adiposity at 8 weeks	—

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026