Paclitaxel Poliglumex and Capecitabine in Treating Patients With Metastatic Breast Cancer

Inclusion criteria

DISEASE CHARACTERISTICS: * Histologic or cytologic confirmation of breast cancer with clinical evidence of metastatic disease * No bone metastases as the only evidence of metastasis * Measurable disease, defined as at least one measurable lesion * No non-measurable disease, defined as all other lesions, including small lesions (longest diameter \< 2.0 cm) and truly non-measurable lesions, which include the following: * Bone lesions * Leptomeningeal disease * Ascites * Pleural/pericardial effusion * Inflammatory breast disease * Lymphangitis cutis/pulmonis * Abdominal masses not confirmed and followed by imaging techniques * Cystic lesions * No known brain metastasis * HER2 negative disease by immunohistochemistry and/or fluorescent in situ hybridization * Diagnostic tissue and operative and pathology reports from breast cancer diagnosis and/or diagnosis of metastatic breast cancer must be available * Hormone receptor status * Not specified PATIENT CHARACTERISTICS: * Males or females are eligible * Menopausal status: not specified * Life expectancy ≥ 3 months * ECOG performance status 0 or 1 * Any serum estradiol level allowed * Hemoglobin \> 8.0 g/dL * Absolute neutrophil count ≥ 1500/mL * Platelet count ≥ 100,000/mL * Bilirubin ≤ 1.5 times upper limit of normal (ULN) * Alkaline phosphatase ≤ 2.5 times ULN * AST and ALT ≤ 2.5 times UNL * Calcium normal * Creatinine clearance ≥ 30 mL/min * Not pregnant or nursing * Negative pregnancy test * Women of childbearing potential or their sexual partners must be willing to employ adequate contraception (as determined by the treating physician) for the duration of the study and for 30 days after treatment has ended * No stage III or IV invasive, non-breast malignancies in ≤ 5 years prior to registration * No history of allergy or hypersensitivity to capecitabine, paclitaxel, or fluorouracil * No prior unanticipated severe reaction to fluoropyrimidine therapy * No known DPD deficiency * No known, existing uncontrolled coagulopathy * No uncontrolled concurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, uncontrolled hypertension, or psychiatric illness/social situations that would limit compliance with study requirements * No lack of physical integrity of the upper gastrointestinal tract, clinically significant malabsorption syndrome, or inability to take oral medication * No significant medical condition that would make treatment or follow-up on this protocol difficult or problematic, in the opinion of the treating oncologist * No preexisting neuropathy \> grade 0 PRIOR CONCURRENT THERAPY: * No other concurrent cytotoxic agents, investigational drugs, immunotherapy, radiation therapy or hormonal therapy * Capecitabine must not be administered together with antiviral drugs * No concurrent allopurinol, metronidazole, or sorivudine (or its chemically-related analogues, such as brivudine) * Cimetidine must be discontinued at least 2 weeks prior to start of study treatment and must be avoided while taking capecitabine * Patients receiving bisphosphonates are eligible for this study * No prior chemotherapy for metastatic disease * Prior anthracycline and/or taxane in the neoadjuvant or adjuvant setting allowed if completed ≥ 6 months prior to registration * Unlimited prior hormonal therapy allowed in the neoadjuvant, adjuvant, or metastatic setting * No HIV-positive individuals receiving combination anti-retroviral therapy * No major surgery, chemotherapy, or immunologic therapy ≤ 4 weeks prior to registration * No radiotherapy ≤ 4 weeks prior to registration, except to a non-target lesion only * Prior radiation to a target lesion is permitted only if there has been clear progression of the lesion since radiation was completed * If patient receives single dose radiation for palliation, they may immediately proceed to registration without waiting 4 weeks * Neoadjuvant and/or adjuvant therapy must be completed \> 6 months prior to registration * No current or recent use (≤ 2 weeks prior to registration) of aspirin, anticoagulants or thrombolytic agents * Agents to maintain patency of a vascular access device is permitted