Assessment of Potential Interactions Between Intravenous Cocaine and Atomoxetine - 1

Phase 1, Double-Blind, Placebo-Controlled Multiple Dose Assessment of Potential Interactions Between Intravenous Cocaine and Atomoxetine

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00265265

Enrollment

Registered

2005-12-14

Start date

2005-08-31

Completion date

Unknown

Last updated

2017-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cocaine-Related Disorders

Keywords

Cocaine Dependence

Brief summary

The purpose of this study is to assess potential interactions between intravenous (i.v.) cocaine and atomoxetine (Strattera) administered orally in four escalating doses.

Interventions

DRUGAtomoxetine

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

18 Years to 45 Years

Healthy volunteers

Inclusion criteria

* 18-45 years of age who are not seeking treatment at the time of the study * Must be able to provide written informed consent * Must be within 20 percent of ideal body weight and weigh at least 45 kg * Must meet DSM0IV diagnostic criteria for cocaine abuse or dependence * Must currently be using cocaine as confirmed by a positive BE * If female and of child bearing potential, must agree to the use of birth control

Exclusion criteria

\- please contact the site directly for more information

Design outcomes

Primary

Measure	Time frame
Safety	—
Cardiovascular responses	—

Secondary

Measure	Time frame
Cocaine craving	—
Abuse Liability	—
Psychological Effects of Cocaine	—
pharmacokinetic assessment	—
Mood and personality assessments	—

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026