Heart Failure, Congestive
Conditions
Keywords
dexamethasone, diuretic, congestive heart failure
Brief summary
The purpose of this study is to determine whether glucocorticoids have potent diuretic effects in patients with congestive heart failure.
Detailed description
Glucocorticoids are known to have pronounced physiological effects in the kidney. Conventional teaching dictates that it should be used with caution in patients with congestive heart failure due to its fluid and sodium retention effects. Surprisingly, despite the widespread prevalence of this belief within the medical community, there are few data to support it. In fact, several small animal studies have documented its striking diuretic effects due to increased renal plasma flow and glomerular filtration rate without changes in the glomerular filtration fraction. We design this study to determine whether glucocorticoids have a potent diuretic effect in patients with heart failure.
Interventions
DRUGdexamethasone
Sponsors
Hebei Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Congestive heart failure patients due to any cause * Patients with normal cortical function * Congestive heart failure patients who are on diuretic therapy * Clinically stable and body weight maintained the same for at least 3 days without signs of fluid retention
Exclusion criteria
* Patient refusal * Signs of infection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| urine volume | — |
| urine electrolyte excretion (urine sodium, urine potassium, urine chloride), and urine creatinine. | — |
| serum electrolyte (serum sodium, serum potassium, serum chloride), serum creatinine, serum urea, serum uric Acid. | — |
| fractional sodium excretion | — |
| glomerular filtration rate (calculated by Cockroft and Gault formula). | — |
Countries
China
Outcome results
None listed