Investigation of Genetic Risk of Cardiovascular Disease in Prospective Cohort Study

Conditions

Cerebral Infarction, Coronary Disease, Healthy, Myocardial Infarction

Brief summary

Cardiovascular disease is a complex multifactorial and polygenic disorder that is thought to result from an interaction between a person's genetic make up and various environmental factors. Although many studies have revealed that several genetic variants increase the risk of cardiovascular disease, the results of these studies remain controversial. The purpose of this study is to identify polymorphisms that confer susceptibility to cardiovascular disease and to clarify the adequacy of reported susceptibility gene polymorphisms. To complete this purpose, we will prospectively study over 5,000 local residents in whom relationship between these polymorphisms and occurrence of cardiovascular disease over 5 years.

Ohashi Y, Ichihara S, Yamamoto K, Kitamura Y, Matsubara T, Beppo R, Kinoshita F, Kato TS, Toyoda Y, Kawamura Y, Matsuo H, Ichida K, Yokota M, Nakatochi M.

2026-01-27

10.1136/rmdopen-2025-006414

Epigenome-wide association of myocardial infarction with DNA methylation sites at loci related to cardiovascular disease.

Nakatochi M, Ichihara S, Yamamoto K, Naruse K, Yokota S, Asano H, Matsubara T, Yokota M.

2017-05-1571 citations

10.1186/s13148-017-0353-3

Plasma resistin concentration determined by common variants in the resistin gene and associated with metabolic traits in an aged Japanese population.

Asano H, Izawa H, Nagata K, Nakatochi M, Kobayashi M, Hirashiki A, Shintani S, Nishizawa T, Tanimura D, Naruse K, Matsubara T, Murohara T, Yokota M.

2009-09-0160 citations

10.1007/s00125-009-1517-2

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

50 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* Healthy subjects who undergo community-based annual health check in Kitanagoya city

Countries

Japan

Contacts

Primary ContactMitsuhiro Yokota, MD, PhD

myokota@dpc.aichi-gakuin.ac.jp+81-52-759-2111

Backup ContactMitsuhiro Yokota, MD, PhD

mitsuhiro.yokota@theranos-inst.com+81-52-744-5515

Outcome results