Asthma
Conditions
Keywords
Sport, Asthma, Treatment, Airway inflammation
Brief summary
International studies have shown that elite athletes have a high prevalence of respiratory symptoms and asthma as compared to normal subjects. It is unclear whether the increased prevalence of asthma in elite athletes reflects traditional asthma or whether it is a special form of sports asthma. The treatment of elite athletes with asthma seems to vary widely, and only a few studies have focused on the treatment of elite athletes with asthma. Further knowledge of the pathogenesis of sports asthma would lead to a greater understanding and better treatment of the condition. This study will investigate the type of airway inflammation in elite athletes and examine the effect of treatment with inhaled steroids in combination with long-acting beta-agonists versus placebo in the same group.
Interventions
DRUGSeretide
Combination of inhaled corticosteroids (250 microgr) and inhaled long-acting beta2-agonists (25 microgr)
DRUGPlacebo
Inhaled sugar powder in a placebo inhaler
Sponsors
Imperial College London
Anti Doping Danmark
GlaxoSmithKline
The Research Foundation of Bispebjerg Hospital
Ragnhild Ibsens Legat For Medicinsk Forskning
Bispebjerg Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Elite athletes * Informed consent * Doctor diagnosed asthma
Exclusion criteria
* Current smoker or more than 10 pack-years * Pregnancy, breast feeding or planning pregnancy during the study. * ICS within the last 4 weeks prior to visit 1.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eucapnic voluntary hyperventilation (EVH) | End of study |
| Exhaled Nitric Oxide | End of study |
Secondary
| Measure | Time frame |
|---|---|
| Respiratory symptoms | End of study |
| Lung function | End of study |
Countries
Denmark
Outcome results
None listed