Effect of BNP (Brain Natriuretic Peptides) on Endothelial Dysfunction Induced by Coronary Angioplasty

Phase 4 Study of Patients Receiving BNP or NTG (IV) During Angioplasty, Re-examined 24 Hours Later Using the Flow-mediated Brachial Artery Dilation Study, and Blood Assays for Pro BNP and ET1

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00262574

Enrollment

500

Registered

2005-12-07

Start date

2005-07-31

Completion date

2013-06-30

Last updated

2011-08-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease

Keywords

endothelial disfunction, BNP, PCI, coronary artery disease

Brief summary

Patients receiving BNP or nitroglycerin (IV) during the angioplasty procedure. 24 h after the procedure, vascular reactivity will be re-examined using the brachial artery flow-mediated dilatation study. Blood assays for ET-1, pro-BNP, and various inflammatory markers will be checked before and 24 h after the procedure. It is our hypothesis that endothelial function will be better in the BNP treated patients compared to the NTG treated patients

Interventions

DRUGNesiritide,

PCI

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

SUPPORTIVE_CARE

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

coronary artery disease -

Exclusion criteria

CHF and/or reduced LV function, or renal failure with Creatinine \>2mg% \-

Design outcomes

Primary

Measure	Time frame
FMD	3 years

Countries

Israel

Contacts

Primary ContactYonathan Hasin, prof.

yhasin@poria.health.gov.il97246652649

Backup ContactDiab gahnim, Dr

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026