Benzodiazepines
Conditions
Brief summary
We hypothesized that patient will success in benzodiazepine withdrawal if they get melatonin to solve sleep-problems which commonly occur during benzodiazepine withdrawal. Former heroin addicts, currently in Methadone maintenance treatment, who are also abusing benzodiazepine, started self benzodiazepine withdrawal, and got for 6 weeks melatonin (5mg/day, taken every night) or placebo and after 1 week, additional 6 weeks with placebo or melatonin (double blind for what got first).Success The benzodiazepine withdrawal success was evaluated by urine for benzodiazepines, and sleep quality was evaluated using PSQI questionnaire (baseline,and after weeks 6, 7, 13)
Detailed description
A total of 100 patients will participate. Follow-up of benzodiazepines in urine after study and 6 months later will be evaluated, as well as sleep quality (using PSQI)
Interventions
DRUGMelatonin
Sponsors
Tel-Aviv Sourasky Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Former opiates addicts, currently in methadone maintenance treatment, and abusing benzodiazepines who intend to withdrawal * adults (\>=18y)
Exclusion criteria
* non abusing benzodiazepine * Refuse making benzodiazepines withdrawal * non methadone maintenance treatment patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Stop benzodiazepine abuse(Urine) | — |
Secondary
| Measure | Time frame |
|---|---|
| sleep quality (self report- PSQI) | — |
Countries
Israel
Contacts
Primary ContactEinat Peles, Ph.D.
Outcome results
None listed