Cardiovascular Disease, Sarcopenia
Conditions
Keywords
sarcopenia, resistance training, strength training, skeletal muscle, elderly, cholesterol, aging, cardiovascular disease, nutrition, inflammation, lipids
Brief summary
The purpose of this study is to examine the effect of dietary cholesterol administered as whole egg or egg white (control)on muscle mass gain with resistance training in a young old population of men and women (age 50-69). It is hypothesized that dietary cholesterol will be significantly associated to muscle mass gain.
Detailed description
The primary objective of this proposal is to have 36 men and women (age 50-69) perform 12 weeks of resistance exercise training for the purpose of inducing skeletal muscle hypertrophy. These individuals will consume either 0, 1, or 3 whole eggs per day in a double-blind design to test the hypothesis that dietary cholesterol is essential for skeletal muscle hypertrophy. If so proven, this will confirm a very strong association between dietary cholesterol and hypertrophy observed in a previous study of 51 men and women (age 60-69). The current proposal is using a randomized double-blind, placebo controlled design to provide the most conclusive evidence that dietary cholesterol plays an essential role in skeletal muscle hypertrophy. The secondary objective of this proposal is to test the hypothesis that increased dietary cholesterol consumption in the context of an exercise program does not alter blood cholesterol concentrations or other cardiovascular risk factors.
Interventions
BEHAVIORALResistance Training
12 weeks, 3 times a week whole body resistance training
BEHAVIORALSedentary
Absence of physical activity
Sponsors
Texas A&M University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
50 Years to 69 Years
Healthy volunteers
Yes
Inclusion criteria
* men and women aged 50-69 * able to perform exercise testing and training
Exclusion criteria
* blood pressure \> 160/100 * cardiac arrhythmias * cancer * hernia * aortic aneurysm * kidney disease * lung disease * total cholesterol \> 240 mg/dl or \< 160 mg/dl * current use of cholesterol lowering medications * actively participating in \>1 hour per week of resistance training
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary: Strength and muscle gain (DEXA) | after 12 weeks of resistance training |
Secondary
| Measure | Time frame |
|---|---|
| Secondary: Blood lipids, inflammatory markers, blood pressure | after 12 weeks of resistance training |
Countries
United States
Outcome results
None listed