Ischemic Heart Disease
Conditions
Keywords
Aspirin treatment, Aspirin resistance, Coronary bypass surgery
Brief summary
Aspirin was proved to be the drug preventing vein grafts from closure and improving clinical outcome after coronary artery bypass surgery. It appears to be effective when being prescribed as early as first 48 hr. after the operation without increasing the incidence of bleeding complications. the exact effective dose is not known.
Interventions
PROCEDURECoronary artery bypass surgery
Sponsors
Sheba Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Patients undergoing Coronary artery bypass surgery * Patients who signed Informed Consent Form
Exclusion criteria
* Concomitant valve surgery or carotid surgery or off-pump surgery * Need for anticoagulation therapy for any reason * Another antiplatelet medications at least 7 days prior to surgery * Contra-indication for aspirin treatment * Thrombocytopenia / thrombocytopathia * NSAIDs treatment for chronic medical conditions * Reluctance to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dysrhythmias | — |
| Mortality | — |
| Perioperative MI | — |
| Perioperative stroke | — |
| Bleeding / reopen / transfusion | — |
| Ventilation | — |
| Inotropic support | — |
Secondary
| Measure | Time frame |
|---|---|
| In-hospital stay | — |
| Non-fatal cardiac events - MI, recurrence of angina, dysrhythmias | — |
| Need for repeat revascularization | — |
| ICU stay | — |
Countries
Israel
Outcome results
None listed