Microvascular Reactivity.

Transdermal Application of Acetylcholine and Nitroglycerin Without Iontophoresis.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00259701

Enrollment

Registered

2005-11-29

Start date

2005-06-30

Completion date

2005-09-30

Last updated

2006-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes, Retinopathy, Vascular Pathology

Keywords

endothelium, iontophoresis, acetylcholine, nitroglycerin, vasodilation

Brief summary

This study attempts to test capillary responses to various challenges without the need for iontophoresis (electrical current).

Detailed description

Studies of microvascular responsiveness often employ iontophoresis to fascilitate drug absorption. Iontophoresis is a confounding stimulus in such studies, and we are attempting to create tests of the microvasculature that do not require iontophoretic drug delivery.

Interventions

DEVICELaser Doppler Flowmetry with topical acetylcholine and nitroglycerin

Study design

Observational model

DEFINED_POPULATION

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

diabetic. -

Exclusion criteria

not on nitrates or mydriatic eye drops within 48 hours. \-

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026