High-dose Periop Statins for Prevention of DVT

High-dose Statin Therapy in the Perioperative Period and DVT Prevention.

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00259662

Enrollment

Registered

2005-11-29

Start date

2005-11-30

Completion date

2007-08-31

Last updated

2016-12-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gynecologic Oncological Pelvic/Abdominal Surgery

Keywords

cancer--ovarian, cancer--endometria, deep vein thrombosis, statin therapy in perioperative period

Brief summary

This study is designed to determine if the use of atorvastatin (Lipitor), a member of the HMG coA reductase inhibitor class of drugs referred to as statins, will reduce inflammatory responses and deep vein thrombosis formation when given in high doses in the perioperative period.

Interventions

DRUGatorvastatin

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Masking

DOUBLE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* gynecologic tumor scheduled for resection

Exclusion criteria

* prior reaction to statins * renal insufficiency * liver disease * h/o alcoholism * prior h/o DVT or hypercoagulability * concurrent medications that significantly affect cytochrome P450 3A4 * breast feeding or pregnancy

Design outcomes

Primary

Measure	Time frame
Decrease in incidence of deep vein thrombosis	—

Secondary

Measure	Time frame
Decrease in inflammatory mediator release.	—

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026