Chlorhexidine vs Povidone Iodine in Alcoholic Solutions for Prevention of Central Venous Catheter Infection

Prevention of Central Venous Catheter Infections : Comparison of the Efficacy of Skin Disinfection With 5% Povidone Iodine in Alcoholic Solution Versus 0.25% Chlorhexidine, 0.025 Benzalkonium and 4% Benzylic Alcohol

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00259350

Enrollment

520

Registered

2005-11-29

Start date

2004-05-31

Completion date

2006-04-30

Last updated

2009-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ICU Patients Requiring a Central Venous Access

Keywords

Central venous catheter, Skin disinfection, Antisepsis, Nosocomial infection, Catheter infection

Brief summary

The best antiseptic solution for cateheter care remains unknown.High concentration in aquous solution or low concentration in alcoholic solution of chlorhexidine actbetter than povidone iodine in aquous solutions. No study has compare alcoholic formulations of low concentration of chlorhexidine and povidone iodine for skin disinfection prior to insertion of central venous catheters. To compare the incidence of central venous catheter colonization after skin disinfection with either an alcoholic solution of povidone iodine or a combination of 0.5% chlorhexidine, 0.025% Benzalkonium and 4% benzylic alcohol. To compare the incidence of catheter related bacteremia in the to study groups. To compare the local and general tolerance of the two antiseptic formulations

Interventions

DRUGSkin disinfection

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients over 18 yeras of age * Requiring an internal jugular or sub-clavian central venous catheter for their care during at least 72 h * Informed consent signed up

Exclusion criteria

* Bacteriemic infection not under control * extensive cutaneous infection * Women with childbearing potential

Design outcomes

Primary

Measure	Time frame
Prevention of catheter colonization	—

Secondary

Measure	Time frame
Prevention of catheter related bacteremia	—
Prevention of a positive culture of the catheter whaterver the threshold	—
Local and general tolerance	—

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026