A Protocol for the Use of Chlorhexidine Gluconate Saturation for the Reduction of Dental Biofilm Formation on Polymethylmethacrylate Restoration

Examination of the Immersion of Provisional Crown Material in Chlorhexidine Gluconate on Dental Plaque Formation in Vivo

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00259181

Enrollment

Registered

2005-11-29

Start date

2005-01-31

Completion date

Unknown

Last updated

2010-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental Plaque

Keywords

chlorhexidine gluconate, polymethylmethacrylate, Anti-Bacterial Agents

Brief summary

Chlorhexidine gluconate (CHX), as an anti plaque agent, is commonly used with a variety of products. In this study we, the investigators at Hadassah Medical Organization, intend to examine the efficacy of a single dip in CHX of provisional restoration prior to oral cementation. If the protocol is effective, we intend to calibrate it and recommend clinical use of the protocol. The examination of biofilm formation will be both with electron microscope and confocal scanning laser microscope.

Interventions

PROCEDUREsaturation of polymethylmethacrylate with chlorhexidine gluconate to reduce in vivo plaque formation

Study design

Allocation

NON_RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Masking

SINGLE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Yes

Inclusion criteria

* Any volunteer without systemic condition

Exclusion criteria

* Intake of antibiotic drug three months prior to experiment

Design outcomes

Primary

Measure	Time frame
calibration of a preventative protocol for biofilm formation measured by confocal scanning laser microscope and scanning electron microscope	—

Countries

Israel

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026