Living Donors
Conditions
Keywords
Living donors, Nephrectomy, Kidney transplantation, Randomized Controlled Trial, Laparoscopy
Brief summary
The purpose of this study is to compare the effects of hand-assisted laparoscopic and mini-incision muscle-splitting donornephrectomy on living kidney donors. The hypothesis is that the mini-incision is not inferior to the laparoscopic technique.
Detailed description
Living kidney donation has become an important source for kidney transplantation because of insufficient numbers of post mortem kidney donations. To reduce the surgical trauma of the donor operation and improve postoperative recovery minimal invasive techniques have developed. Especially the laparoscopic and the hand-assisted laparoscopic technique gained wide popularity. Minimal invasive open techniques have had less publicity. One of those open techniques is to perform the open donornephrectomy by means of an anterolateral approach. A transverse subcostal incision of 10 cm or less is made. The abdominal wall is opened by splitting the muscles and sparing the nerves. Staying in the retroperitoneal space the kidney is freed and taken out. Laparoscopic approaches have especially become more popular after the hand-assisted technique had developed. By means of an 8 cm transverse suprapubic skin incision and a vertical midline fascia incision the abdominal cavity is opened and a hand is inserted in the abdomen through an air tight sleeve. Three more trocarts are needed for the insufflation, the video camera and surgical instruments to perform a transperitoneal donornephrectomy. The hand in the abdomen assisting in the procedure has especially increased the sense of safety compared to the full laparoscopic technique without compromising the advantages of the laparoscopic technique. So far no prospective or retrospective study has been done comparing the hand-assisted laparoscopic with the mini-incision muscle-splitting technique. Most studies that have been done comparing the (hand-assisted) laparoscopic technique with more invasive open techniques resulted in favour of the former technique. Comparison(s): The study compares the effects of hand-assisted laparoscopic and mini-incision muscle-splitting donornephrectomy on living kidney donors.
Interventions
PROCEDURELiving donornephrectomy
Sponsors
University Medical Center Groningen
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Accepted as living kidney donor by local protocol * 18 years or older * Excellent understanding of Dutch language * Able to be operated on by both surgical techniques * Having read patient information and signed informed consent
Exclusion criteria
* Previous surgery using subcostal incision(s) * Not meeting the inclusion criteria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Triple pain measurement using linear Visual Analogue Scale (at rest, at coughing and in supine position lifting of straight legs) | — |
Secondary
| Measure | Time frame |
|---|---|
| - CRP levels in first three days after the donor operation (indicative of the magnitude of the surgical trauma) | — |
| - Abdominal wall muscle function (testing the functional integrity of the abdominal muscles) | — |
Countries
Netherlands
Outcome results
None listed