Allergy
Conditions
Brief summary
The study will find out how effective rupatadine is in the treatment of mosquito bite symptoms in adult patients allergic to mosquito bites.
Detailed description
Mosquito-bite symptoms include wheals and pruritic bite papules. Oral antihistamines have shown to decrease whealing ang accompanying pruritus in placebo-controlled trials. Subjects will be treated for 4 days, and exposed to experimental mosquito bite at day 3.
Interventions
DRUGRupatadine
DRUGPlacebo
Sponsors
J. Uriach and Company
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Recent history of suffering from mosquito-bite reactions. * At least 5 mm diameter mosquito-bite wheal from Aedes aegypti laboratory mosquitoes
Exclusion criteria
* Pregnancy or lactating females * Oral antihistamines, corticosteroids or non-steroid anti-inflammatory drugs (NSAID) use within two weeks before the study. * Severe or moderate systemic illness * Allergy to rupatadine or other antihistamines * Anaphylaxis from mosquito bites
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bite lesion size (squared mm) | — |
Secondary
| Measure | Time frame |
|---|---|
| Pruritus on a Visual Analog Scale | — |
Countries
Finland
Contacts
Primary ContactTimo Reunala, Prof.
Outcome results
None listed