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Comparison of Two Psychotherapy Treatments for Depressed Women With a History of Sexual Abuse

Interpersonal Psychotherapy for Depressed Women With Sexual Abuse Histories

Status
Completed
Phases
Phase 1Phase 2
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00257400
Enrollment
70
Registered
2005-11-22
Start date
2003-05-31
Completion date
2007-08-31
Last updated
2014-01-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression

Keywords

major depressive disorder, psychotherapy, childhood sexual abuse, trauma

Brief summary

This study will compare the effectiveness of individual versus interpersonal psychotherapy in treating depressed women with a history of sexual abuse.

Detailed description

Depression is a common but serious mental disorder that affects millions of people each year. Depression can severely impact people's lives, causing them to often feel sad and hopeless, as well as affecting people's sleep patterns, concentration, and energy levels. Women with a history of abuse are at an increased risk for developing symptoms of depression. However, treatments such as interpersonal psychotherapy and individual psychotherapy have been known to reduce symptoms of depression. This study will compare the effectiveness of individual and interpersonal psychotherapy in improving depressive symptoms and daily functioning in depressed women with a history of sexual abuse. Participants in this study will undergo a two-part screening interview at the Strong Adult Ambulatory Clinic. This screening will include both written questionnaires and face-to-face interviews regarding any experiences of sexual or physical abuse; suicidal thoughts; family relationships; and current attitudes, thoughts, or feelings. Participants who meet all criteria will then be randomly assigned to receive one of two treatments: interpersonal psychotherapy or individual psychotherapy, which is considered usual care. All treatment sessions will be held at the Strong Adult Ambulatory Clinic. Participants assigned to receive interpersonal psychotherapy will attend weekly 50-minute sessions with a therapist. Interpersonal psychotherapy will focus on current interpersonal stressors in daily life, such as difficulties in close relationships or at work. Treatment will also help participants examine the relationship between their mood changes and interpersonal problems. Participants assigned to receive individual psychotherapy will undergo cognitive-behavioral therapy, supportive counseling, or a combination of the two. Participants will work with their therapists to decide upon a treatment plan designed to help changes in mood and other difficulties in daily life. The number and length of treatment sessions for this group will be determined on an individual basis. For all participants, evaluations consisting of questionnaires similar to those from the initial screening will be completed at mid-treatment, post-treatment, and 3 months after treatment.

Interventions

Interpersonal Psychotherapy

Individual Psychotherapy

Sponsors

National Institute of Mental Health (NIMH)
CollaboratorNIH
University of Rochester
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Meets DSM-IV criteria for unipolar major depressive disorder * History of childhood sexual abuse before the age of 18 * Seeking outpatient psychotherapy treatment in a community mental health center

Exclusion criteria

* Meets DSM-IV criteria for major depression with psychotic features, bipolar disorder, schizophrenia, or mental retardation * Active alcohol or substance abuse within 3 months of study entry date

Design outcomes

Primary

MeasureTime frame
Hamilton Rating Scale for DepressionMeasured at pre-treatment and Weeks 10, 24, and 36
Beck Depression InventoryMeasured at pre-treatment and Weeks 10, 24, and 36
Structured Clinical Interview for DSM-IV DiagnosesMeasured at pre-treatment and Weeks 10, 24, and 36

Secondary

MeasureTime frame
Social Adjustment ScaleMeasured at pre-treatment and Weeks 10, 24, and 36
Medical Outcomes SurveyMeasured at pre-treatment and Weeks 10, 24, and 36
Post Traumatic Stress Disorder (PTSD) Symptom ScaleMeasured at pre-treatment and Weeks 10, 24, and 36

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026