Gastroenteritis
Conditions
Brief summary
Background: Pedialyte and Gatorade are advocated for the treatment of dehydration in viral gastroenteritis, but there is limited evidence to support their use. Objective: To examine the efficacy, safety and palatability of Pedialyte, Gatorade, and a New Oral Rehydration Solution (NS). Design: Randomized double blind. Setting: Inpatient, community hospital. Patients/Interventions: 75 consecutive adult patients (m/f=44/33) admitted with viral gastroenteritis were randomized to receive Gatorade, Pedialyte or NS for 48 hours. A yogurt/rice diet was allowed ad libitum. Measurements: Stool and urine output, electrolytes, fluid intake, body weight, hematocrit and palatability of solutions. Limitations: Smaller sample size and higher drop out (20%).
Interventions
DRUGGatorade, Pedialyte and New Solution
Sponsors
Augusta University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
19 Years to 80 Years
Inclusion criteria
* Subjects were included if they had mild-to-moderate diarrhea, with mildly sunken eyes and a clinical assessment of dehydration of less than 5%, a serum sodium concentration between 130-150 mEq/L, adequate general health and nutrition, a BUN/creatinine ratio of \>20 and with a normal pulse rate for age and degree of fever and adequate skin turgor
Exclusion criteria
* Patients were excluded if they had hyperthermia (\>39.0º C), serum sodium \>150 mEq/L or \<130 mEq/L, white cell count \>15,000, bloody diarrhea (dysentery), abnormal cardiovascular or renal function or an underlying metabolic or nutritional disorder and most importantly, if the clinical assessment of dehydration was \>7% that suggested a need for intravenous fluids.
Countries
India
Outcome results
None listed