Acute Myocardial Infarction
Conditions
Keywords
Acute myocardial infarction, primary angioplasty, myocardial reperfusion, thrombus aspiration
Brief summary
In patients with acute ST-segment elevation myocardial infarction (STEMI), percutaneous coronary intervention (PCI) may cause thrombus dislodgment and impaired microcirculatory reperfusion. This study was designed to test the hypothesis that thrombus aspiration before standard PCI may improve acute myocardial reperfusion, measured by ST-segment resolution (STR) and myocardial blush grade (MBG), compared with standard PCI.
Detailed description
Consecutive STEMI patients, admitted within 12 hours of symptom onset and scheduled for primary PCI are randomly assigned to two treatment strategies: standard PCI including stenting and abciximab (group1) or thrombus aspiration with Pronto™ extraction catheter (Vasc.solutions, Minneapolis) before standard PCI (group2). Patients with cardiogenic shock, previous infarction or thrombolytic therapy are excluded.
Interventions
DEVICECoronary thrombus aspiration catheter
Sponsors
Niguarda Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
No minimum to 80 Years
Healthy volunteers
No
Inclusion criteria
* ST-segment elevation myocardial infarction patients undergoing primary angioplasty within 12 hours from symptom onset.
Exclusion criteria
* Cardiogenic shock, previous infarction, previous coronary bypass surgery,bundle branch block or pacemaker induced rythm, controindications to IIb/IIIa inhibitors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ST-segment resolution immediately after primary angioplasty | — |
| Myocardial Blush grade after angioplasty. | — |
Secondary
| Measure | Time frame |
|---|---|
| Coronary TIMI flow grade, | — |
| distal embolization, | — |
| no reflow | — |
Countries
Italy
Outcome results
None listed