Bladder Diseases, Interstitial Cystitis, Urinary Incontinence
Conditions
Keywords
NO, mRNA-expression, pathophysiology, painful bladder syndrome
Brief summary
Painful bladder syndrome (PBS)/interstitial cystitis (IC) may be due to the actions of nitric oxide (NO) in the bladder tissue. NO is a gaseous substance with a very short half-life, synthesized by a group of NO-synthase-enzymes in many tissues. The goal of this study is to illuminate bladder tissue production of NO in individuals with PBS and healthy individuals, by quantification of NO and NO-enzyme expression by different molecular biological methods.
Interventions
PROCEDURETissue examination for protein- and mRNA-expression of NO
Sponsors
Zealand University Hospital
Copenhagen University Hospital at Herlev
Study design
Observational model
DEFINED_POPULATION
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* PBS/IC according to International Continence Society (ICS) * Cystoscopy with bladder distension and deep biopsies within last 5 years * Cystometry within last 5 years * Normal urine culture within last month Inclusion Criteria (for control group): * Benign non-invasive bladder disease * No PBS/IC * Normal urine culture * No functional bladder disease of known nature (ex. infravesical obstruction)
Exclusion criteria
* Age under 18 years * Inability to understand instructions * Pregnancy and lactation
Countries
Denmark
Outcome results
None listed