Cancer, Cervix
Conditions
Keywords
NIH, Non-Invasive diagnosis of cervical tissue, Los Alamos/NIH
Brief summary
In general, to determine the sensitivity of light transport to tissue from morphological features of clinical significance. Determine how specific structural features contribute to light scattering. Investigate light scattering differences in tumorigenic and nontumorigenic cells. Develop and implement quantitative and sensitive methods for measuring morphological properties. Clinical measurements.
Detailed description
Patients undergoing a colposcopy will also have spectroscopy measurements taken and an extra biopsy of suspicious tissue.
Interventions
PROCEDUREColposcopy, Spectroscopy, and Biopsy
During the colposcopy or LEEP (Loop Electrical Excision Procedure) procedure, or during pelvic exams before surgery after the doctor applies 3% acetic acid to the cervix, the doctor then positions the colposcope to take pictures of the patient's cervix. Digital pictures are taken of the patient's cervix under white light using a colposcopy imaging system. These pictures are annotated by the doctor during the appointment to mark the spectroscopy sites.
Sponsors
University of New Mexico
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with abnormal Pap smears who are referred for colposcopy.
Exclusion criteria
include: * Anyone of the male sex since this study focuses on cervical cell abnormalities * Any woman who has had a hysterectomy, LEEP, or chemotherapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The objective of this study is to determine whether non-invasive measurements of light transport through tissue can identify pre-cancerous and cancerous conditions. | 6 years |
Countries
United States
Outcome results
None listed