Familial Adenomatous Polyposis
Conditions
Keywords
Familial adenomatous polyposis patient with 5 or more adenomatous polyps in the colon or ileoanal pouch
Brief summary
The purpose of this study is to assess if curcumin, a commonly used food spice, can regress colorectal adenomatous polyps in patients with familial adenomatous polyposis, an inherited form of colorectal cancer.
Interventions
DRUGcurcumin
curcumin 500 mg by mouth, three times a day for 9 months
Sponsors
Johns Hopkins University
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Familial adenomatous polyposis * 18 years of age or older * 5 or more adenomas of colorectum or ileum
Exclusion criteria
* Female patient of child bearing age not on effective birth control pills * Pregnant women * White blood cell (WBC) count less than 4000 * Platelets (Plts) less than 100,000 * Blood urea nitrogen (BUN) greater than 25 * Creatine greater than 1.5 * Patients unable to stop non-steroidal anti-inflammatory drugs (NSAIDs) during duration of trial * Malignancy * Patient with active bacterial infections of gastroesophageal reflux disease or peptic ulcer disease * Patient on warfarin or anti-platelet drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| polyp number and size | one year |
Secondary
| Measure | Time frame |
|---|---|
| side effects and medication compliance | one year |
Outcome results
None listed