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The Genetic Basis for Vulnerability to Substance Abuse

Allelic Linkage in Substance Abuse

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT00247819
Enrollment
8000
Registered
2005-11-02
Start date
1992-08-31
Completion date
2006-02-28
Last updated
2017-01-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Substance Abuse

Keywords

Substance abuse

Brief summary

This investigation seeks to better define the genetic basis for vulnerability to substance abuse.

Detailed description

Dopamine (DA), a neurotransmitter helping to mediate reward and reinforcement, has been putatively linked to the development of substance abuse, alcohol abuse, and alcoholism. Identification of specific vulnerability-association alleles for receptors, other molecules within the reward mediating system, and other genes that may predispose individuals to the development of such disorders is the goal of the study. This investigation will help elucidate the genetic underpinnings of substance abuse, potentially leading to the improved methods to diagnose those at risk and to help develop better therapeutic interventions.

Interventions

PROCEDUREBlood draw

Sponsors

National Institute on Drug Abuse (NIDA)
Lead SponsorNIH

Study design

Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* Substance abusers * Allow for blood draw

Exclusion criteria

* Cognitively impaired

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026